General
Preferred name
QC-01-175-1
Synonyms
QC-01–175 ()
QC-01-175 ()
QC-01¨C175 ()
P&D ID
PD124764
CAS
2267290-96-8
Tags
probe
PROTAC
available
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
Gray Laboratory Probes
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2].
DESCRIPTION QC-01-175 is a functional degrader of pathogenic tau protein . It is a bifunctional molecule that simultaneously engages tau and cereblon (CRBN; a component of the E3 ubiquitin ligase complex) to trigger tau ubiquitination and proteasomal degradation. Such molecules can be described as PROTACs (proteolysis targeting chimeras). Cereblon engagement is mediated by the probe's module, and tau recruitment is achieved by a variant of the tau PET tracer T807 (). QC-01-175 retains the tau ligand-binding capacity of the parent T807, but with reduced off-target MAO inhibition liability. (GtoPdb)
MOA Degrader (PROTAC) (Chemical Probes.org)
Compound Sets
6
Chemical Probes.org
qc-01-175
Gray Laboratory Probes
Guide to Pharmacology
10544
High-quality chemical probes
PD124764
MedChem Express Bioactive Compound Library
HY-134850
PROTAC-DB
1344
External IDs
5
Properties
(calculated by RDKit )
Molecular Weight
626.25
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
14
Ring Count
6
Aromatic Ring Count
4
cLogP
2.31
TPSA
171.82
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.12
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
MAPT
PROTACs
Tau Protein
tau
Pathway
Neuronal Signaling
Target class
Extracellular protein
Target subclass
Microtubule Associated Protein
Control
QC-03-075
Source data